达肝清对小鼠免疫性肝损伤的保护作用

周小雷<sup>1</sup>; 王 硕<sup>1</sup>; 邓家刚<sup>2</sup>; 范丽丽<sup>2</sup>; 袁经权<sup>1</sup>

引用本文:	周小雷, 王硕, 邓家刚, 范丽丽, 袁经权.达肝清对小鼠免疫性肝损伤的保护作用[J].广西植物,2009,(6):863-865.[点击复制]
	ZHOU Xiao-Lei, WANG Shuo, DENG Jia-Gang, FAN Li-Li, YUAN Jing-Quan.Protection of Daganqing on immunological liver injury of mouse[J].Guihaia,2009,(6):863-865.[点击复制]

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达肝清对小鼠免疫性肝损伤的保护作用
周小雷¹, 王硕¹, 邓家刚², 范丽丽², 袁经权¹
1.广西壮族自治区药用植物园南方药物研究检测中心, 南宁 530023;2.广西中医学院, 南宁 530001

摘要:

采用卡介苗(BCG)+脂多糖(LPS)造成免疫性肝损伤动物模型,观察达肝清对小鼠血清ALT、AST活性及肝组织匀浆SOD、MDA、GSH-PX水平的影响,并观察肝组织病理学改变。结果表明:达肝清可明显降低小鼠血清中ALT、AST活性,同时能减少肝匀浆MDA含量,并能使降低的肝匀浆SOD、GSH-PX活性升高。该实验属首次报道。

关键词: 达肝清免疫性肝损伤保肝

DOI：

分类号:Q946

基金项目:

Protection of Daganqing on immunological liver injury of mouse

ZHOU Xiao-Lei, WANG Shuo, DENG Jia-Gang, FAN Li-Li, YUAN Jing-Quan

1.Southern Medicine Research Test Center, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China;2.Guangxi Traditional Chinese Medical University, Nanning 530001, China 1.Southern Medicine Research Test Center, Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China; 2.Guangxi Traditional Chinese Medical University, Nanning 530001, China

Abstract:

The models of hepatic damage of immunity were induced by BCG+LPS. The level of ALT,AST in serum,the activities of MDA,SOD,GSH-PX in liver homogenate,and the coefficient of liver were assayed.in addition,dimensions of hepatic damage in the histopathology were observed. We found that Daganqing could significantly decrease the serum transaminase activities and MDA content,and prevent the reduction of SOD,GSH-PX activities in liver homogenate. These experiments of the article were the first report for Daganqing.

Key words: Daganqing immunological liver injury hepatoprotection